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Journal Articles

Neutron scattering

Nakagawa, Hiroshi; Matsuo, Tatsuhito*

Furontoranna Jikiden Sobunri Kaiseki Purotokoru; Jikken Igaku Bessatsu Saikyo No Suteppu UP Shirizu, p.222 - 227, 2022/07

Although the principle of neutron scattering is the same as that of X-ray scattering, it provides unique information due to the different interaction with the sample during the scattering process. Small-angle neutron scattering and quasi-elastic neutron scattering are promising methods to analyze the structure and association of proteins in droplets and their molecular dynamics. Neutron scattering experiments, which require nuclear reactors or accelerators as sources, are limited in Japan, and overseas facilities may be used if necessary.

Journal Articles

X-ray scattering $$cdot$$ neutron scattering

Nakagawa, Hiroshi; Matsuo, Tatsuhito*

Jikken Igaku, 39(10), p.1667 - 1673, 2021/06

X-ray and neutron scattering are methods to reveal the structural state, assembly state, and intermolecular interactions of biomolecules in solution. Synchrotron X-rays provide highly accurate solution scattering data in a short time. Deuterated labeling can be used to make specific molecules invisible in neutron beams, allowing us to selectively observe only the molecules of interest in a molecular population. Neutron beams with energies comparable to thermal fluctuations are also suitable for measuring molecular motion. Although its application to the analysis of phase separation phenomena is currently limited, it is an effective method for analyzing phase separation states on the nano- to meso-scale and for studying the liquid-liquid phase separation.

Journal Articles

Prediction of protein-DNA interactions

Sarai, Akinori*; Kono, Hidetoshi

Jikken Igaku, 26(7), p.1099 - 1105, 2008/04

no abstracts in English

Journal Articles

Cooperative target recognition of transcription factors associated with conformational changes

Sarai, Akinori*; Kono, Hidetoshi

Jikken Igaku, 25(10), p.77 - 84, 2007/06

no abstracts in English

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